The Tlaxcallans, or Tlaxcaltecs, are an indigenous Nahua people who originate from Tlaxcala, Mexico. The Confederacy of Tlaxcala was instrumental in overthrowing the Aztec Empire in 1521, alongside conquistadors from the Kingdom of Spain. The Tlaxcallans remained allies of the Spanish for 300 years until the Independence of Mexico in 1821.

Tlaxcala, officially the Free and Sovereign State of Tlaxcala, is one of the 32 federal entities that comprise the Federal Entities of Mexico. It is divided into 60 municipalities and the capital city is Tlaxcala de Xicohténcatl.