The tobacco industry playbook, tobacco strategy or simply disinformation playbook describes a strategy devised by the tobacco industry in the 1950s to protect revenues in the face of mounting evidence of links between tobacco smoke and serious illnesses, primarily cancer. Much of the playbook is known from industry documents made public by whistleblowers or as a result of the Tobacco Master Settlement Agreement. These documents are now curated by the UCSF Truth Tobacco Industry Documents project and are a primary source for much commentary on both the tobacco playbook and its similarities to the tactics used by other industries, notably the fossil fuel industry. It is possible that the playbook may even have originated with the oil industry.

Merchants of Doubt: How a Handful of Scientists Obscured the Truth on Issues from Tobacco Smoke to Global Warming is a 2010 non-fiction book by American historians of science Naomi Oreskes and Erik M. Conway. It identifies parallels between the global warming controversy and earlier controversies over tobacco smoking, acid rain, DDT, and the hole in the ozone layer. Oreskes and Conway write that in each case "keeping the controversy alive" by spreading doubt and confusion after a scientific consensus had been reached was the basic strategy of those opposing action. In particular, they show that Fred Seitz, Fred Singer, and a few other contrarian scientists joined forces with conservative think tanks and private corporations to challenge the scientific consensus on many contemporary issues.