The Tobu Isesaki Line is a Japanese railway line operated by the private railway company Tobu Railway, extending from Tōbu-Dōbutsu-Kōen Station in Saitama to Isesaki Station in Gunma Prefecture. The Isesaki Line can refer to the entire section between Asakusa - Isesaki and Oshiage - Hikifune, but from March 2012, the 41.0 km (25.5 mi) section south of Tōbu-Dōbutsu-Kōen was branded as the Tobu Skytree Line in conjunction with the opening of the Tokyo Skytree tower.

Gunma Prefecture is a landlocked prefecture of Japan located in the Kantō region of Honshu. Gunma Prefecture has a population of 1,937,626 and has a geographic area of 6,362 km2. Gunma Prefecture borders Niigata Prefecture and Fukushima Prefecture to the north, Nagano Prefecture to the southwest, Saitama Prefecture to the south, and Tochigi Prefecture to the east.