The Tohono Oʼodham Nation is the collective government body of the Tohono Oʼodham tribe in the United States. The Tohono Oʼodham Nation governs four separate sections of land with a combined area of 2.8 million acres (11,330 km2), approximately the size of Connecticut and the second largest Indigenous land holding in the United States. These lands are located within the Sonoran Desert of south central Arizona and border the Mexico–United States border for 74 miles (119 km) along its southern border. The Nation is organized into 11 local districts and employs a tripartite system of government. Sells is the Nation's largest community and functions as its capital. The Nation has approximately 34,000 enrolled members, the majority of whom live off of the reservations.

The Tohono Oʼodham are a Native American people of the Sonoran Desert, residing primarily in the U.S. state of Arizona and the northern Mexican state of Sonora. The United States federally recognized tribe is the Tohono Oʼodham Nation.