The Tonawanda Kardex was an American football team active between 1916 and 1921. It played its games in Tonawanda, New York, a suburb of Buffalo with close ties to North Tonawanda, New York where American Kardex was founded. The team is most notable for its one game as a member of the American Professional Football Association in the 1921 season. They are easily the shortest-lived team in the league's history, and the shortest-lived known team in North American major league sports history.

Tonawanda is a city in Erie County, New York, United States. The population was 15,129 at the 2020 census. It is at the northern edge of Erie County, south across the Erie Canal from North Tonawanda, east of Grand Island, and north of Buffalo. It is part of the Buffalo-Niagara Falls metropolitan area.