The Tony Award for Best Performance by a Leading Actress in a Musical is awarded to the best actress in a musical, whether a new production or a revival. The award has been given since 1948, but the nominees who did not win have only been publicly announced since 1956.

Nanette Fabray was an American actress, singer and dancer. She began her career performing in vaudeville as a child and became a musical-theatre actress during the 1940s and 1950s, acclaimed for her role in High Button Shoes (1947) and winning a Tony Award in 1949 for her performance in Love Life. In the mid-1950s, she served as Sid Caesar's comedic partner on Caesar's Hour, for which she won three Emmy Awards, and appeared with Fred Astaire in the film musical The Band Wagon. From 1979 to 1984, she played Katherine Romano, the mother of lead character Ann Romano, on the TV series One Day at a Time. She also appeared as the mother of Christine Armstrong in the television series Coach.