Anthony Carroll Knowles is an American politician and businessman who served as the seventh governor of Alaska from 1994 to 2002. Barred from seeking a third consecutive term as governor in 2002, he ran unsuccessfully for the U.S. Senate in 2004 and again for governor in 2006. In September 2008, Knowles became president of the National Energy Policy Institute, a non-profit energy policy organization funded by billionaire George Kaiser's family foundation, and located at the University of Tulsa.

The 2004 United States Senate election in Alaska took place on November 2, 2004, alongside other elections to the United States Senate in other states as well as elections to the United States House of Representatives, various state and local elections, and the presidential election of that year. Incumbent Republican U.S. Senator Lisa Murkowski of Anchorage, sought election to her first full term after being appointed by her father Frank Murkowski to serve out the rest of the latter's unexpired term when he resigned in December 2002 to become Governor of Alaska. Her main challenger was Democratic former governor Tony Knowles, her father's predecessor as governor. Murkowski won by a slight margin. As of 2022, Senator Murkowski’s vote total of 149,773 votes remains the most raw votes she has ever received during any of her runs for the US Senate.