Totonacapan refers to the historical extension where the Totonac people of Mexico dominated, as well as to a region in the modern states of Veracruz and Puebla. The historical territory was much larger than the currently named region, extending from the Cazones River in the north to the Papaloapan River in the south and then west from the Gulf of Mexico into what is now the Sierra Norte de Puebla region and into parts of Hidalgo. When the Spanish arrived, the Totonac ethnicity dominated this large region, although they themselves were dominated by the Aztec Empire. For this reason, they allied with Hernán Cortés against Tenochtitlán. However, over the colonial period, the Totonac population and territory shrank, especially after 1750 when mestizos began infiltrating Totonacapan, taking political and economic power. This continued into the 19th and 20th centuries, prompting the division of most of historical Totonacpan between the states of Puebla and Veracruz. Today, the term refers only to a region in the north of Veracruz where Totonac culture is still important. This region is home to the El Tajín and Cempoala archeological sites as well as Papantla, which is noted for its performance of the Danza de los Voladores.

The Totonac are an indigenous people of Mexico who reside in the states of Veracruz, Puebla, and Hidalgo. They are one of the possible builders of the pre-Columbian city of El Tajín, and further maintained quarters in Teotihuacán. Until the mid-19th century they were the world's main producers of vanilla.