A train wheel or rail wheel is a type of wheel specially designed for use on railway tracks. The wheel acts as a rolling component, typically press fitted onto an axle and mounted directly on a railway carriage or locomotive, or indirectly on a bogie, also called a truck. The powered wheels under the locomotive are called driving wheels. Wheels are initially cast or forged and then heat-treated to have a specific hardness. New wheels are machined using a lathe to a standardized shape, called a profile, before being installed onto an axle. All wheel profiles are regularly checked to ensure proper interaction between the wheel and the rail. Incorrectly profiled wheels and worn wheels can increase rolling resistance, reduce energy efficiency and may even cause a derailment. The International Union of Railways has defined a standard wheel diameter of 920 mm (36 in), although smaller sizes are used in some rapid transit railway systems and on ro-ro carriages.

An axle or axletree is a central shaft for a rotating wheel or gear. On wheeled vehicles, the axle may be fixed to the wheels, rotating with them, or fixed to the vehicle, with the wheels rotating around the axle. In the former case, bearings or bushings are provided at the mounting points where the axle is supported. In the latter case, a bearing or bushing sits inside a central hole in the wheel to allow the wheel or gear to rotate around the axle. Sometimes, especially on bicycles, the latter type of axle is referred to as a spindle.