The Trans-Caspian Railway is a railway that follows the path of the Silk Road through much of western Central Asia. It was built by the Russian Empire during its expansion into Central Asia in the 19th century. The railway was started in 1879, following the Russian victory over Khokand. Originally it served a military purpose of facilitating the Imperial Russian Army in actions against the local resistance to their rule. However, when Lord Curzon visited the railway, he remarked that he considered its significance went beyond local military control and threatened British interests in Asia.

In the 16th century, the Tsardom of Russia embarked on a campaign to expand the Russian frontier to the east. This effort continued until the 19th century under the Russian Empire, when the Imperial Russian Army succeeded in conquering all of Central Asia. The majority of this land became known as Russian Turkestan—the name "Turkestan" was used to refer to the area due to the fact that it was and is inhabited by Turkic peoples, excluding the Tajiks, who are an Iranian ethnicity. Upon witnessing Russia's absorption of the various Central Asian realms, the British Empire sought to reinforce India, triggering the Great Game, which ended when both sides eventually designated Afghanistan as a neutral buffer zone.