The city of Karachi is a major transport hub of Pakistan. The Karachi port and airport are major gateways to Pakistan. The Karachi Railway stations transports the major part of Pakistan's trade with other countries.

The Port of Karachi is one of South Asia's largest and busiest deep-water seaports, handling about 60% of the nation's cargo located in Karachi, Pakistan. It is located on the Karachi Harbour, between Kiamari Azra Langri, Manora, and Kakapir, and close to Karachi's main business district and several industrial areas. The geographic position of the port places it in close proximity to major shipping routes such as the Strait of Hormuz. It is also ideally located to offer gateway services to the maritime trade for the Central Asian Republics (CARs). The administration of the port is carried out by the Karachi Port Trust, which was established in 1857.