Mali's transportation infrastructure is regarded as poor, even by regional standards, and deficiencies have limited economic growth and development. Nevertheless, improvements have been noted in the early 2000s. Most of the transportation in Mali consists of cars, planes, and boats.

The Dakar–Niger Railway connects Dakar, Senegal to Koulikoro, Mali. The name refers to the Niger River, not the Republic of Niger. It serves many cities in Senegal, including Thiès, and in Mali, including Kayes, Kita, Kati, Bamako. The line covers a course of 1,287 km of which 641 km lies in Mali.