Rhône-Alpes is a major European transit hub, linking northern France and Europe to the Mediterranean area. Millions travel along its motorways in summertime from Paris to holidays at the sea. The E15 Euroroute runs through the region. There are international airports at Lyon, Grenoble and Saint-Étienne and many other minor airports and airfields.

Lyon-Jean Macé station is a railway station in the 7th arrondissement of Lyon. It is situated on the Paris–Marseille railway and the Lyon–Geneva railway. The station is a part of the Lyon urban area rapid transit network. It was aimed to decongest the major stations Part-Dieu and Perrache while allowing access to the public transport of Lyon (TCL). The station began operation on 13 December 2009.