Transportation safety in the United States encompasses safety of transportation in the United States, including automobile crashes, airplane crashes, rail crashes, and other mass transit incidents, although the most fatalities are generated by road incidents annually killing 32,479 people in 2011 to over 42,000 people in 2022. The number of deaths per passenger-mile on commercial airlines in the United States between 2000 and 2010 was about 0.2 deaths per 10 billion passenger-miles. For driving, the rate was 150 per 10 billion vehicle-miles: 750 times higher per mile than for flying in a commercial airplane.

The Federal Aviation Administration (FAA) is a U.S. federal government agency within the U.S. Department of Transportation which regulates civil aviation in the United States and surrounding international waters. Its powers include air traffic control, certification of personnel and aircraft, setting standards for airports, and protection of U.S. assets during the launch or re-entry of commercial space vehicles, powers over neighboring international waters were delegated to the FAA by authority of the International Civil Aviation Organization.