The Treaty of Medicine Creek was an 1854 treaty between the United States, and nine tribes and bands of Indians, occupying the lands lying around the head of Puget Sound, Washington, and the adjacent inlets. The tribes listed on the Treaty of Medicine Creek are Nisqually, Puyallup, Steilacoom, Squawskin, S'Homamish, Stehchass, T'Peeksin, Squi-aitl, and Sa-heh-wamish. The treaty was signed on December 26, 1854, by Isaac I. Stevens, governor and superintendent of Indian Affairs of the territory at the time of the signing, along with the chiefs, head-men and delegates of the stated tribes. For the purpose of the treaty, these representatives who signed the treaty were stated to have been, "regarded as one nation, on behalf of said tribes and bands, and duly authorized by them."

The Puyallup are a Lushootseed-speaking Southern Coast Salish people indigenous to the Puget Sound region of Washington state. They are primarily enrolled in and represented by the Puyallup Tribe of Indians, a federally-recognized Indian tribe located near Tacoma.