The Tri-Cities is the region comprising the cities of Kingsport, Johnson City, and Bristol and the surrounding smaller towns and communities in Northeast Tennessee and Southwest Virginia. All three cities are located in Northeast Tennessee, while Bristol has a twin city of the same name in Virginia.

East Tennessee is one of the three Grand Divisions of Tennessee defined in state law. Geographically and socioculturally distinct, it comprises approximately the eastern third of the U.S. state of Tennessee. East Tennessee consists of 33 counties, 30 located within the Eastern Time Zone and three counties in the Central Time Zone, namely Bledsoe, Cumberland, and Marion. East Tennessee is entirely located within the Appalachian Mountains, although the landforms range from densely forested 6,000-foot (1,800 m) mountains to broad river valleys. The region contains the major cities of Knoxville and Chattanooga, Tennessee's third and fourth largest cities, respectively, and the Tri-Cities, the state's sixth largest population center.