Triple quadrupole mass spectrometer
A triple quadrupole mass spectrometer (TQMS), is a tandem mass spectrometer consisting of two quadrupole mass analyzers in series, with a (non-mass-resolving) radio frequency (RF)–only quadrupole between them to act as a cell for collision-induced dissociation. This configuration is often abbreviated QqQ, here Q1q2Q3.
Waters Quattro II triple quadropole mass spectrometer (center). This photo was taken in the old mass spec facility in Whitmore Lab of Pennsylvania State University.
Quadrupole from a Waters TQ-S triple quadrupole mass spectrometer
Settings associated with selecting m/z values in both mass filters of a triple quadrupole mass analyzer
Schematic of a triple quadrupole mass spectrometer
Tandem mass spectrometry, also known as MS/MS or MS2, is a technique in instrumental analysis where two or more stages of analysis using one or more mass analyzer are performed with an additional reaction step in between these analyses to increase their abilities to analyse chemical samples. A common use of tandem MS is the analysis of biomolecules, such as proteins and peptides.
A quadrupole time-of-flight hybrid tandem mass spectrometer.
An ion trap mass spectrometer is an example of a tandem mass spectrometry in time instrument.
Chromatography trace (top) and tandem mass spectrum (bottom) of a peptide.
