Trujillo Alto is a town and municipality of Puerto Rico located in the Northern Coastal Plain, on the boundary between the karst zone and Sierra de Luquillo, north of Caguas, and Gurabo; southeast of San Juan, and west of Carolina. Trujillo Alto is part of the San Juan Metropolitan Area, which includes the municipalities of Bayamón, Guaynabo, Cataño, and Toa Baja. The city is spread over 6 barrios and Trujillo Alto Pueblo. It is part of the San Juan-Caguas-Guaynabo Metropolitan Statistical Area.

Trujillo Alto barrio-pueblo is a barrio and the administrative center (seat) of Trujillo Alto, a municipality of Puerto Rico. Its population in 2010 was 673.