Tsegede is a woreda in Tigray Region, Ethiopia, named after the historic province of Tsegede. Located in the Western Zone of Tigray, Tsegede is bordered on the south and west by the Amhara Region, on the northwest by Kafta Humera, and on the north by Welkait. The administrative center of this woreda is Ketema Nigus. Other towns in Tsegede include Dansha and Idaga Hamus.

The Western Zone is a zone in the Tigray Region of Ethiopia. It is subdivided into three woredas (districts); from north to south they are Kafta Humera, Welkait and Tsegede. The largest town is Humera. The Western Zone is bordered on the east by the North Western Zone, the south by the Amhara Region, the west by Sudan and on the north by Eritrea. Starting from the late 17th C., internal boundaries are clearly shown, with 37 maps displaying a boundary that is located well south of the Tekeze River, or even south of the Simien mountains. Welkait is explicitly included within a larger Tigray confederation ; it is briefly mapped as part of Amhara in 1891-1894 and part of Gondar from 1944-1990. At other periods it appears independent or part of a larger Mezaga lowland region.