Tsu Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Ise Province and in Iga Province in what is part of now modern-day Tsu, Mie. It was centered around Tsu Castle. Tsu Domain was controlled by the tozama Tōdō clan throughout most of its history.

Iga Province was a province of Japan located in what is today part of western Mie Prefecture. Its abbreviated name was Ishū (伊州). Iga is classified as one of the provinces of the Tōkaidō. Under the Engishiki classification system, Iga was ranked as an "inferior country" and a "near country".