Tsugaru Nobuhira was the second daimyō of Hirosaki Domain in northern Mutsu Province, Honshū, Japan. His courtesy title was Etchū-no-kami, and his Court rank was Junior Fifth Rank, Lower Grade.

Hirosaki Domain , also known as Tsugaru Domain , was a tozama feudal domain of Edo period Japan It is located in Mutsu Province, in northern Honshū. The domain was centered at Hirosaki Castle, located in the center of what is now the city of Hirosaki in Aomori Prefecture. It was ruled by the Tsugaru clan. A branch of the family ruled the adjoining Kuroishi Domain.