The Tsugaru clan was a Japanese samurai clan who ruled the northwestern half of what is now Aomori Prefecture in the Tōhoku region of Japan under the Edo period Tokugawa shogunate. The Tsugaru were daimyō of Hirosaki Domain and its semi-subsidiary, Kuroishi Domain. The Tsugaru were in constant conflict with their former overlords, the Nanbu clan of adjoining Morioka Domain. During the Boshin War of 1868-69, the Tsugaru clan fought mostly on the pro-imperial side, although it did briefly join the Ōuetsu Reppan Dōmei. In the Meiji period, the former daimyō became part of the kazoku peerage, with Tsugaru Tsuguakira receiving the title of hakushaku (Count). The main Tsugaru line is now extinct.

This is a list of Japanese clans. The old clans (gōzoku) mentioned in the Nihon Shoki and Kojiki lost their political power before the Heian period, during which new aristocracies and families, kuge, emerged in their place. After the Heian period, the samurai warrior clans gradually increased in importance and power until they came to dominate the country after the founding of the first shogunate.