The Turin–Milan railway is a major Italian railway that links the cities of Turin and Milan. The railway is double track, standard gauge and fully electrified at 3 kV DC. It connects the cities of Settimo Torinese, Chivasso, Santhià, Vercelli, Novara, Magenta and Rho. Since February 2006 high-speed trains have operated over the Turin–Milan high-speed line between Turin and Novara. The remainder of the high-speed line between Novara and Milan was opened in December 2009, when the Bologna–Florence high-speed line and the remaining sections of the Rome–Naples high-speed railway line and the Naples–Salerno high-speed line are opened, completing the high-speed network between Turin and Salerno.

The Turin–Modane railway is the international rail connection from Turin, Italy to Modane, France. It passes through the Susa Valley and the Fréjus Rail Tunnel. Together with the French Culoz–Modane railway it is often called "Fréjus Railway" or "Mont Cenis Railway". A major landslide in August 2023 forced its closure for most likely over one year.