Tuscola County is a county in the Thumb region of the U.S. state of Michigan. As of the 2020 census, the population was 53,323. The county seat is Caro. The county was created by Michigan Law on April 1, 1840, from land in Sanilac County and attached to Saginaw County for administrative purposes. The Michigan Legislature passed an act on March 2, 1850, that empowered the county residents to organize governmental functions.

Caro is a city in and the county seat of Tuscola County, Michigan, United States. The population was 4,328 at the 2020 census and 4,145 at the 2000 census.