Twenty-Second Air Force is a Numbered Air Force component of Air Force Reserve Command (AFRC). It was activated on 1 July 1993 and is headquartered at Dobbins Air Reserve Base, Georgia.

A Numbered Air Force (NAF) is a type of organization in the United States Air Force that is subordinate to a major command (MAJCOM) and has assigned to it operational units such as wings, squadrons, and groups. A Component Numbered Air Force (C-NAF) has the additional role as an Air Force Component Command exercising command and control over air and space forces supporting a Unified Combatant Command. Unlike MAJCOMs, which have a management role, a NAF is a tactical organization with an operational focus, and does not have the same functional staff as a MAJCOM. Numbered air forces are typically commanded by a major general or a lieutenant general.