"Twenty Two" is episode 53 of the American television series The Twilight Zone. The story was adapted by Rod Serling from a short anecdote in the 1944 Bennett Cerf Random House anthology Famous Ghost Stories, which itself was an adaptation of "The Bus-Conductor", a short story by E. F. Benson published in The Pall Mall Magazine in 1906. It was one of the six episodes of the second season which were shot on videotape in a short-lived experiment aimed to cut costs, and was directed by Jack Smight.

The Twilight Zone is an American fantasy science fiction horror anthology television series created and presented by Rod Serling, which ran for five seasons on CBS from October 2, 1959, to June 19, 1964. Each episode presents a standalone story in which characters find themselves dealing with often disturbing or unusual events, an experience described as entering "the Twilight Zone", often with a surprise ending and a moral. Although often considered predominantly science-fiction, the show's paranormal and Kafkaesque events leaned the show much closer to fantasy and horror. The phrase "twilight zone" has entered the vernacular, used to describe surreal experiences.