Twiggs County is a county located in the central portion of the U.S. state of Georgia. As of the 2020 census, the population was 8,022. The county seat is Jeffersonville. The county was created on December 14, 1809, and named for American Revolutionary War general John Twiggs.

Central Georgia is an eleven-county region in the U.S. state of Georgia. It abuts the Atlanta metropolitan area, just to the north, and is anchored by both the Macon and Warner Robins metropolitan areas.