Twiztid is an American hip hop duo from Livonia, Michigan, known for both their horror-themed lyrics and rock-influenced sound. Formed in 1997, Twiztid is composed of rappers Jamie "Madrox" Spaniolo and Paul "Monoxide" Methric. Spaniolo and Methric are also members of the group House of Krazees with Bryan "The R.O.C." Jones, which formed in 1992.

Jamie Michael Spaniolo, known professionally as Jamie Madrox, is an American rapper from Detroit, Michigan, and performs as a member of the hip hop groups Twiztid and House of Krazees. Spaniolo's stage name is a reference to Marvel Comics's character Multiple Man.