Two Prudential Plaza is a 64-story skyscraper located in the Loop area of Chicago, Illinois. At 995 feet (303 m) tall, it is the seventh-tallest building in Chicago as of 2022 and the 28th-tallest in the U.S., being only five feet from 1,000 feet, making it the closest of any building under 1,000. Built in 1990, the building was designed by the firm Loebl Schlossman & Hackl, with Stephen T. Wright as the principal in charge of design. It has received eight awards, including winning the Best Structure Award from the Structural Engineers Association of Illinois in 1995.

The Loop, one of Chicago's 77 designated community areas, is the central business district of the city and is the main section of Downtown Chicago. Home to Chicago's commercial core, it is the second largest commercial business district in North America after Midtown Manhattan in New York City, and contains the headquarters and regional offices of several global and national businesses, retail establishments, restaurants, hotels, and theaters, as well as many of Chicago's most famous attractions. It is home to Chicago's City Hall, the seat of Cook County, and numerous offices of other levels of government and consulates of foreign nations. The intersection of State Street and Madison Street is the origin point for the address system on Chicago's street grid. Most of Grant Park's 319 acres are in the eastern section of the community area. The Loop community area is bounded on the north and west by the Chicago River, on the east by Lake Michigan, and on the south by Roosevelt Road.