Tyler County is a county in the U.S. state of West Virginia. As of the 2020 census, the population was 8,313. Its county seat is Middlebourne. The county was founded in 1814 and is named after John Tyler, Sr., father of President John Tyler.

John Tyler Sr. was an American lawyer, planter, politician and judge who served in the Virginia House of Delegates and became 15th Governor of Virginia and later United States district judge of the United States District Court for the District of Virginia. He was the father of U.S. President John Tyler.