Tyrrell County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population was 3,245, making it the least populous county in North Carolina. Its county seat is Columbia. The county was created in 1729 as Tyrrell Precinct and gained county status in 1739.

Columbia is a town in Tyrrell County, North Carolina, United States. The population was 610 at the 2020 census. It is the county seat of Tyrrell County.