U.S. Route 101 (US 101), is a major north–south U.S. Highway in Oregon that runs through the state along the western Oregon coastline near the Pacific Ocean. It runs from the California border, south of Brookings, to the Washington state line on the Columbia River, between Astoria, Oregon, and Megler, Washington.

The Oregon Coast is a coastal region of the U.S. state of Oregon. It is bordered by the Pacific Ocean to its west and the Oregon Coast Range to the east, and stretches approximately 362 miles (583 km) from the California state border in the south to the Columbia River in the north. The region is not a specific geological, environmental, or political entity, and includes the Columbia River Estuary.