U.S. Route 12 or U.S. Highway 12 (US 12) is an east–west United States Numbered Highway, running from Aberdeen, Washington, to Detroit, Michigan, for almost 2,500 miles (4,000 km). The highway has mostly been superseded by Interstate 90 (I-90) and I-94, but, unlike most U.S. Highways that have been superseded by an Interstate, US 12 remains intact as an important link for local and regional destinations. The highway's western terminus in Aberdeen is at an intersection with US 101, while the highway's eastern terminus in Downtown Detroit is at the corner of Michigan and Cass avenues, near Campus Martius Park.

Interstate 90 (I-90) is an east–west transcontinental freeway and the longest Interstate Highway in the United States at 3,021 miles (4,862 km). It begins in Seattle, Washington, and travels through the Pacific Northwest, Mountain West, Great Plains, Midwest, and the Northeast, ending in Boston, Massachusetts. The highway serves 13 states and has 15 auxiliary routes, primarily in major cities such as Chicago, Cleveland, Buffalo, and Rochester.