U.S. Route 127 (US 127) is a 758-mile-long (1,220 km) north–south U.S. Highway in the eastern half of the United States. The southern terminus of the route is at US 27 in Chattanooga, Tennessee. The northern terminus is at Interstate 75 (I-75) near Grayling, Michigan. Since 1987, it has been the core of the annual World's Longest Yard Sale, also known as the Highway 127 Corridor Sale, which now stretches 690 miles (1,110 km) from Addison, Michigan, to Gadsden, Alabama. The sale, held every August, was started to demonstrate that the older U.S. Highway System has something to offer that the Interstate Highway System does not. In Michigan, US 127 tripled in length in 2002, taking mileage from its parent, US 27.

Pikeville is a city in Bledsoe County, Tennessee. The population was 1,824 at the 2020 census. It is also the county seat of Bledsoe County.