U.S. Route 127 (US 127) is a 758-mile-long (1,220 km) north–south U.S. Highway in the eastern half of the United States. The southern terminus of the route is at US 27 in Chattanooga, Tennessee. The northern terminus is at Interstate 75 (I-75) near Grayling, Michigan. Since 1987, it has been the core of the annual World's Longest Yard Sale, also known as the Highway 127 Corridor Sale, which now stretches 690 miles (1,110 km) from Addison, Michigan, to Gadsden, Alabama. The sale, held every August, was started to demonstrate that the older U.S. Highway System has something to offer that the Interstate Highway System does not. In Michigan, US 127 tripled in length in 2002, taking mileage from its parent, US 27.

U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.