U.S. Route 129 (US 129) is a north–south United States highway that travels 63.5 miles (102.2 km) through the westernmost part of North Carolina. Traveling from the Georgia state line near Bellview, to the Tennessee state line at Deals Gap, it is known for its scenic mountain valley vistas and curvy mountain bends popular with motorcycle and sports car enthusiasts.

North Carolina Highway 143 (NC 143) is a primary state highway in the U.S. state of North Carolina. It runs from the Tennessee state line to NC 28, near the community of Stecoah. It is best known for its 18-mile (29 km) section of the Cherohala Skyway, shared with Tennessee State Route 165.