U.S. Route 158 (US 158) is an east–west United States highway that runs for 350 miles (560 km) from Mocksville to Whalebone Junction in Nags Head, entirely in the state of North Carolina. It is also a critical route that connects the cities of Winston-Salem, Summerfield, and Reidsville with one another.

Mocksville is a town in Davie County, North Carolina, United States. The population was 5,900 at the 2020 census. I-40 leads west to Statesville and Hickory, and east to Winston-Salem and Greensboro. Route 64 heads east to Lexington, and west towards Statesville and Taylorsville. It is the county seat of Davie County.