U.S. Highway 15 (US 15) is a north–south United States Numbered Highway running from Walterboro, South Carolina, to Painted Post, New York. In the U.S. state of North Carolina, the highway runs for 159 miles (256 km) from the South Carolina state line to the south of Laurinburg to the Virginia state line north of Bullock. US 15 travels in concurrency with US 501 for 106 miles (171 km) between Laurinburg and Durham.

U.S. Route 501 is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina at U.S. Route 17 Business. It passes through the states of Virginia, North Carolina and South Carolina. From Durham to Laurinburg, a 108-mile (174 km) section of US 501 overlaps U.S. Route 15. Sections of US 15-501 also share routings with U.S. Route 1 in sections near Sanford, North Carolina and Aberdeen, North Carolina.