U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".

U.S. Route 89 (US 89) is a U.S. Highway in the U.S. state of Arizona that begins in Flagstaff and heads north to the Utah border northwest of Page. US 89 is among the first U.S. Highways established in Arizona between November 11, 1926 and September 9, 1927. Until 1992, US 89 started at the international border in Nogales and was routed through Tucson, Phoenix and Prescott between Nogales and Flagstaff. State Route 79 and State Route 89 are both former sections of US 89.