U.S. Route 160 (US 160), also known as the Navajo Trail, is a U.S. Highway which travels west to east across the Navajo Nation and Northeast Arizona for 159.35 miles (256.45 km). US 160 begins at a junction with US 89 north of Cameron and exits the state into New Mexico south of the Four Corners Monument. Along its journey, the route connects the communities of Tuba City, Moenkopi, Rare Metals, Tonalea, Tsegi, Kayenta, Dennehotso, Mexican Water, Red Mesa, and Teec Nos Pos.

U.S. Route 89 (US 89) is a U.S. Highway in the U.S. state of Arizona that begins in Flagstaff and heads north to the Utah border northwest of Page. US 89 is among the first U.S. Highways established in Arizona between November 11, 1926 and September 9, 1927. Until 1992, US 89 started at the international border in Nogales and was routed through Tucson, Phoenix and Prescott between Nogales and Flagstaff. State Route 79 and State Route 89 are both former sections of US 89.