U.S. Route 19 (US 19) in Pennsylvania closely parallels Interstate 79 (I-79) for its entire length. US 19 enters Pennsylvania from West Virginia in Greene County near Mount Morris. Its northern terminus is at US 20 in the city of Erie. Part of it is named for Commodore Oliver Hazard Perry, hero of the Battle of Lake Erie.

Interstate 79 (I-79) is an Interstate Highway in the Eastern United States, designated from I-77 in Charleston, West Virginia, north to Pennsylvania Route 5 (PA 5) and PA 290 in Erie, Pennsylvania. It is a primary thoroughfare through western Pennsylvania and West Virginia and makes up part of an important corridor to Buffalo, New York, and the Canada–United States border. Major metropolitan areas connected by I-79 include Charleston and Morgantown in West Virginia and Greater Pittsburgh and Erie in Pennsylvania.