U.S. Route 1 (US 1) is a part of the U.S. Highway System that extends from Key West, Florida, to the Canada–United States border at Fort Kent, Maine. In the U.S. state of New York, US 1 extends 21.54 miles (34.67 km) from the George Washington Bridge in Manhattan to the Connecticut state line at Port Chester. It closely parallels Interstate 95 (I-95) for much of its course and does not serve as a major trunk road within the state. It is not concurrent with any other highways besides I-95 and (briefly) US 9, and few other state highways intersect it.

Interstate 95 (I-95) is part of the Interstate Highway System and runs from Miami, Florida, to the Canada–United States border near Houlton, Maine. In the US state of New York, I-95 extends 23.50 miles (37.82 km) from the George Washington Bridge in New York City to the Connecticut state line at Port Chester. The George Washington Bridge carries I-95 across the Hudson River from New Jersey into New York City. There, I-95 runs across Upper Manhattan on the Trans-Manhattan Expressway for 0.81 miles (1.30 km) through Washington Heights. It continues east across the Harlem River on the Alexander Hamilton Bridge and onto the Cross Bronx Expressway. In the Bronx, I-95 leaves the Cross Bronx at the Bruckner Interchange, joining the Bruckner Expressway to its end. North of the interchange with Pelham Parkway, it then continues northeast via the New England Thruway out of New York City into Westchester County and to the Connecticut state line, where I-95 continues on the Connecticut Turnpike.