U.S. Route 1 (US 1) in Washington, D.C., passes through from Arlington, Virginia, to Mount Rainier, Maryland, predominantly along surface streets. However, it forms a few overlaps with other routes.

Interstate 395 (I-395) in Virginia and Washington, D.C., is a 13.79-mile-long (22.19 km) spur route of I-95 that begins at an interchange with I-95 in Springfield and ends at an interchange with US Route 50 (US 50) in Northwest Washington, D.C. It passes underneath the National Mall near the US Capitol and ends at a junction with US 50 at New York Avenue, roughly one mile (1.6 km) north of the 3rd Street Tunnel. Despite its proximity to I-395 in Maryland, the route is unrelated and unconnected.