U.S. Route 20 (US 20) runs its easternmost 153 miles (246 km) in the U.S. state of Massachusetts. The highway crosses the state border from New Lebanon, New York, into Hancock and runs eastward to Boston, where it ends at Route 2 in Kenmore Square. It spends the vast majority of its journey paralleling I-90, which has largely superseded US 20 for through travel. Still, US 20 directly serves many towns and local business areas which the turnpike bypasses.

Hancock is a town in Berkshire County, Massachusetts, United States. It is part of the Pittsfield, Massachusetts Metropolitan Statistical Area. The population was 757 at the 2020 census.