U.S. Route 20 (US 20) is a part of the United States Numbered Highway System that runs from Newport, Oregon, to Boston, Massachusetts. In the U.S. state of New York, US 20 extends 372.32 miles (599.19 km) from the Pennsylvania state line at Ripley to the Massachusetts state line in the Berkshires. US 20 is the longest surface road in New York. It runs near the Lake Erie shore from Ripley to Buffalo and passes through the southern suburbs of Buffalo, the Finger Lakes, the glacial moraines of Central New York, and the city of Albany before crossing into Massachusetts. US 20 connects to all three major north–south Interstate Highways in Upstate New York: Interstate 390 (I-390) near Avon, I-81 south of Syracuse, and I-87 in Albany by way of NY 910F.

Avon is a village in the town of Avon, Livingston County, New York, United States. The village population was 3,394 at the 2010 census, out of 7,146 people in the entire town. The village and town are named after the River Avon in England.