U.S. Route 219 (US 219) is a part of the U.S. Highway System that runs from Rich Creek, Virginia, to West Seneca, New York. In the U.S. state of New York, US 219 extends 67.63 miles (108.84 km) from the Pennsylvania state line at Carrollton to an interchange with the New York State Thruway at exit 55 in West Seneca, southeast of downtown Buffalo. In Cattaraugus County, the area surrounding US 219 is predominantly rural. However, in northern Cattaraugus County, US 219 becomes a freeway leading through Erie County and into the heart of Buffalo. The route serves the villages of Ellicottville and Springville, where it meets New York State Route 242 (NY 242) and NY 39, respectively, and indirectly serves Hamburg via NY 391.

West Seneca is a town in Erie County, New York, United States. The population was 45,500 at the 2020 census. West Seneca is a centrally located interior town of the county, and a suburb of Buffalo. West Seneca, Orchard Park and Hamburg form the inner "Southtowns", a cluster of middle-class suburban towns.