U.S. Route 22 (US 22) is a major west–east route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at US 1/9 at the Newark Airport Interchange.
Old US 22 marker located near the intersection of US 22 and SR 207 in Pickaway County, Ohio
View east along US 22 east of County Route 13 (CR 13) in Weirton, West Virginia
US 22 eastbound in Colonial Park, Pennsylvania, east of Harrisburg
View east along US 22 at Cramer Avenue in Green Brook, New Jersey
United States Numbered Highway System
The United States Numbered Highway System is an integrated network of roads and highways numbered within a nationwide grid in the contiguous United States. As the designation and numbering of these highways were coordinated among the states, they are sometimes called Federal Highways, but the roadways were built and have always been maintained by state or local governments since their initial designation in 1926.
The "final" U.S. Highway plan as approved November 11, 1926
This sign, photographed in 1941 on US 99 between Seattle, Washington, and Portland, Oregon, illustrates one rationale for a federal highway system: national defense.