U.S. Route 22 (US 22) is a United States Numbered Highway stretching from Cincinnati, Ohio, in the west to Newark, New Jersey, in the east. In New Jersey, the route runs for 60.53 miles (97.41 km) from the Easton–Phillipsburg Toll Bridge over the Delaware River in Phillipsburg, Warren County, to Interstate 78 (I-78), US 1/9, and Route 21 at the Newark Airport Interchange in Newark, Essex County. The road first heads through the Phillipsburg–Alpha area as an arterial road before running concurrent with I-78 through mountainous and agricultural sections of western New Jersey between Alpha and east of Clinton in Hunterdon County. For the remainder of the route, US 22 runs to the south of I-78 through mostly suburban areas as a four- to six-lane arterial road, passing through Hunterdon, Somerset, Union, and Essex counties. Along this portion, it intersects US 202 and US 206 in Somerville, I-287 in Bridgewater Township, and the Garden State Parkway in Union.

Phillipsburg is a town located along the Delaware River that is the most populous municipality in Warren County, in the U.S. state of New Jersey. It is part of the Allentown-Bethlehem-Easton, PA-NJ metropolitan statistical area. As of the 2020 United States census, the town's population was 15,249, an increase of 299 (+2.0%) from the 2010 census count of 14,950, which in turn reflected a decline of 216 (−1.4%) from the 15,166 counted in the 2000 census.