U.S. Route 24 (US 24) is a United States Numbered Highway that runs from Minturn, Colorado, to Independence Township, Michigan. In Ohio, it is an expressway and freeway for much of its length, from the Indiana state line to Maumee. From there northeast to the Michigan state line at Toledo, it is a surface highway.

State Route 281 is an east–west state highway in the northwestern portion of the U.S. state of Ohio. Its western terminus is at U.S. Route 24 approximately four miles (6.4 km) northeast of downtown Defiance, and its eastern terminus is at US 6 nearly one mile (1.6 km) north of Bradner. The majority of the route is known as the Defiance Pike.