U.S. Route 250 is a route of the United States Numbered Highway System, and is a spur of U.S. Route 50. It currently runs for 514 miles (827 km) from Richmond, Virginia to Sandusky, Ohio. It passes through the states of Virginia, West Virginia, and Ohio. It goes through the cities of Richmond, Charlottesville, Staunton, and Waynesboro, Virginia; and Wheeling, West Virginia. West of Pruntytown, West Virginia, US 250 intersects and forms a short overlap with its parent US 50.

Sandusky is a city in and the county seat of Erie County, Ohio, United States. Situated along the southern shore of Lake Erie, Sandusky is located roughly midway between Toledo and Cleveland. According to 2020 census, the city had a population of 25,095, and the Sandusky metropolitan area had 115,986 residents.