U.S. Route 250 is a route of the United States Numbered Highway System, and is a spur of U.S. Route 50. It currently runs for 514 miles (827 km) from Richmond, Virginia to Sandusky, Ohio. It passes through the states of Virginia, West Virginia, and Ohio. It goes through the cities of Richmond, Charlottesville, Staunton, and Waynesboro, Virginia; and Wheeling, West Virginia. West of Pruntytown, West Virginia, US 250 intersects and forms a short overlap with its parent US 50.

U.S. Route 219 (US 219) is a part of the U.S. Highway System that travels from Rich Creek, Virginia, to West Seneca, New York. In the U.S. state of West Virginia, the U.S. Highway travels from the Virginia state line near Peterstown to the Maryland state line near Silver Lake.