U.S. Route 250 (US 250) is a United States Numbered Highway that runs from Sandusky, Ohio to Richmond, Virginia. Within the state of Ohio, the route runs from US 6 in Sandusky to the West Virginia border at Bridgeport.

State Route 60 is a north–south state highway that runs the entire length of the U.S. state of Ohio, from the Williamstown Bridge over the Ohio River in Marietta to U.S. Route 6 near Lake Erie in Vermilion. It is the seventh longest state route in Ohio.